Skip to main content

Table 5 Genes absent from all 4 output pools

From: Disruption of Mycobacterium avium subsp. paratuberculosis-specific genes impairs in vivo fitness

Zero output Mtb orthologue Essentiality in H37Rv Protein function in M. tuberculosis
MAP0298 (MAPK_3470) Rv1129c Essential for growth of H37Rv on cholesterol in vitro Probable transcriptional regulator protein
MAP0704 (MAPK_3064) Rv3121 Essential for in vitro growth Probable cytochrome P450 141 Cyp141
MAP0865 (MAPK_2903) Rv0284 Essential for in vitro growth ESX conserved component EccC3 ESX-3 type VII
MAP0908c (MAPK_2860) Rv0966c Non-essential for in vitro growth Hypothetical protein
MAP0977 (MAPK_2791) Rv1013 Required for growth in C57BL/6 J mouse spleen Putative polyketide synthase Pks16
MAP1031c (MAPK_2737) Rv2601 Non-essential for in vitro growth Probable spermidine synthase SpeE
MAP1082c (MAPK_2686) Rv1936 Non-essential for in vitro growth Possible monooxygenase
MAP1195c (MAPK_2573) Rv1467c Non-essential for in vitro growth Probable acyl-CoA dehydrogenase FadE15
MAP1236c (MAPK_2532) Rv2938 Required for growth in C57BL/6 J mouse spleen Probable daunorubicin-dim-transport integral membrane protein ABC transporter DrrC
MAP1576 (MAPK_2192) Rv1866 Non-essential for in vitro growth Hypothetical protein
MAP1584c (MAPK_2184) Rv2897c Essential for in vitro growth Hypothetical protein
MAP1601 (MAPK_2167) n.a.   
MAP1605c (MAPK_2163) Rv1882c Non-essential for in vitro growth Probable short-chain type dehydrogenase/reductase
MAP1822c (MAPK_1946) Rv3903c Non-essential for in vitro growth Hypothetical alanine and proline rich protein
MAP1835c (MAPK_1933) Rv2110c Essential for in vitro growth and encoded proteasome required for persistence in mice Proteasome beta subunit PrcB
MAP1914 (MAPK_1854) Rv2176 Non-essential for in vitro growth Probable transmembrane serine/threonine-protein kinase L PknL (protein kinase L)
MAP2008 (MAPK_1760) Rv2259 n.d. S-nitrosomycothiol reductase MscR
MAP2385c (MAPK_1383) Rv3543c Essential for growth of H37Rv on cholesterol in vitro Probable acyl-CoA dehydrogenase FadE29
MAP2439c (MAPK_1329) Rv1321 Non-essential for in vitro growth Hypothetical protein
MAP2582c (MAPK_1186) Rv1866 Non-essential for in vitro growth Hypothetical protein
MAP2964c (MAPK_0804) Rv1701 Essential for in vitro growth Probable integrase/recombinase
MAP3070 (MAPK_0698) Rv3829c Non-essential for in vitro growth Probable dehydrogenase
MAP3131 (MAPK_0637) Rv0450c Essential for in vitro growth Probable conserved transmembrane transport protein MmpL4
MAP3327c (MAPK_0441) Rv3529c Non-essential for in vitro growth Hypothetical protein
MAP3352c (MAPK_0416) Rv1358 n.d. Probable transcriptional regulatory protein
MAP3420c (MAPK_0348) Rv1705c Non-essential for in vitro growth PPE family protein PPE22
MAP3699c (MAPK_0069) Rv0249c Required for growth in C57BL/6 J mouse spleen Probable succinate dehydrogenase [membrane anchor subunit]
MAP3951c (MAPK_3953) Rv0457c Non-essential for in vitro growth Probable peptidase
MAP4117c (MAPK_4119) Rv0645c Non-essential for in vitro growth Methoxy mycolic acid synthase 1
  1. M. tuberculosis orthologues are assigned based on the KEGG database (Kyoto Encyclopedia Genes and Genomes; http://www.kegg.jp/[56]) and essentiality information is found on Tuberculist. Gene annotation by Li et al shown in first column with Wynne et al annotation in brackets. n.a. = not applicable, n.d. = no data, PPE = Pro-Pro-Glu.