Table 2 Candidate genes for validation

AKR1C1

NM_001195574.1

Putative role in myelin formation

[43]

HBB

NM_001164428.1

Putative role in intraneuronal oxygen homeostasis, reduced in Alzheimer's and Parkinson's disease

[44]

NCAM1

XM_001083697.2

PrP/N-CAM complexes found in prion infected N2a cells

[45]

NR4A2

NM_001266910.2

Mutations related to dopaminergic dysfunction, including Parkinson schizophrenia and depression

[46, 47]

USP16

NM_001260999.2

Depletion of USP16 prevented ATMi from restoring transcription after DSB induction

[48]

CALB1

XM_001085269.2

Plays a protective role in neurodegenerative disorders (depleted in HD)

[49]

DACH1

XM_001082371.2

Required for normal brain development

[50]

LXN

NM_001266988.1

Marker for the regional specification of the neocortex

[51]

PIK3R3

NM_001266826.1

Linked to β-amyloid plaque formation in AD brain

[52]

SAP18

NM_001261034.1

Possibly related to AD

[53]

SERPINA3

NM_001195350.1

Increased in schizophrenia, SNPs affecting onset and duration of AD

[54, 55]

TNFSF10

NM_001266034.1

Implicated in pathogenesis of MS (causing demyelination)

[56]

HBA2

NM_001044724.1

Putative role in intraneuronal oxygen homeostasis, reduced in Alzheimer's and Parkinson's diseases

[44]

GNRH1

NM_001195436.1

Key regulator of the reproductive neuroendocrine system in vertebrates

[57]

IRF3

NM_001135797

Putative protective role against prion infection

[58]

APOC1 *

AK240617.1

Binds to ApoE, risk factor for Alzheimer's disease

[59]

TM7SF3

XM_001099269.2

-

-

MYBPC1

XM_001091952.1

-

-

TTR

NM_001261679

Amyloid neuropathies, interaction with Aβ

[60]