Figure 1

FDG-PET exam in the derivation group. Cardiac function was assessed in sham-operated mice (n = 4) and MI mice (n = 4) using FDG-PET, 24 hours after surgery. A. Representative polar maps of a sham-operated mouse and a MI mouse, in which the left ventricle is divided in 17 segments. In each segment, the indicated number corresponds to the percentage of FDG uptake. The segment was considered necrotic when the FDG uptake was inferior to 50%. Color scale shows the amount of FDG uptake, with darker color indicating lower FDG uptake (necrotic areas) and brighter color indicating high FDG uptake (viable areas). B. Vertical (up) and horizontal (bottom) long axis end-systolic PET images of a MI mouse. White arrows indicate necrotic areas (absent or low FDG uptake). C. LV volumes, EF and infarct size as determined by FDG-PET image analysis. Infarct size was evaluated by the number of necrotic segments (<50% FDG uptake).