Figure 2

Microarray analysis. Cardiac transcriptome of 4 sham-operated mice and 4 MI mice (derivation group) was characterized 24 hours after surgery using microarrays. A. Principal component analysis showing the ability of gene expression data to discriminate MI mice from sham-operated mice. B. M-A plot showing the distribution of the genes in the dataset. The vertical axis displays log2 transformed-fold change and the horizontal axis displays the average signal of each gene. C. Heatmap of differentially expressed genes. For B and C, red color indicates genes up-regulated in MI mice and green color indicates genes down-regulated in MI mice compared to sham mice. Black color indicates genes with comparable expression between MI and sham mice. Significance threshold was 2-fold with a q-value <5%.