Figure 3
From: Allele-specific expression and eQTL analysis in mouse adipose tissue
Cis versus local -eQTLs. Comparison of local and cis-eQTL suggest a much better concordance between the two local-eQTL datasets, than of any of them to cis-eQTLs identified by ASE. In addition reproducibility of cis-eQTLs seems to be independent of their effect size (defined as ratio of expression between the two homozygous alleles). A. Overlap of cis-eQTLs identified in F1 dataset, with local-eQTLs identified in HMDP and F2 studies. F1, HMDP and F2 labels represent the respective datasets. B. Recovery of local-eQTLs, but not cis-eQTLs correlates to effect size of eQTL. Boxplot shows effect sizes of the different overlapping groups in different studies. Red indicates effect sizes in HMDP, blue in F2 and grey in F1. “+ ” indicates local or cis-eQTL, “-” indicates not significant. C. Correlation of ASE ratio in adipose and liver data. Genes are colored according to overlap with local-eQTL studies. Genes that do not show a significant cis-eQTL in adipose are in grey, other colors are as indicated in the figure - “+ ” indicates local or cis-eQTL, “-” indicates not significant.