Figure 4

Target gene prediction. Target genes of miRNAs in the four pluripotency related classes were predicted by microT v4.0 and mapped to KEGG pathways by mirPath. Not all miRNAs in the four pluripotency-related classes were analyzed because some of them are not yet included in the mirPath database. Some miRNAs that have less than 100 target genes were also excluded in this plot. The bubble plot shows the KEGG pathway enrichment of some pluripotency related miRNAs. The bubble color scaled the enrichment score. A larger score means more significant enrichment. The size of the bubble scaled the percentage of the enriched target genes among total target miRNAs of a miRNA. KEGG pathway names are listed at the left of the plot and the function class names of the pathways are listed in the right panel.