Figure 5
ChIP co-enrichment at ncRNA genes. TF co-enrichment, defined as the median log2 ChIP-chip fold enrichment (MLFE), as a function of distance to the nearest ncRNA gene. Plotted in black is a fit to y = b 0 + b 1 e(1/d). Top to bottom: (A) Co-enrichment across YPD experiments from Harbison et al. [11]: b 0 = −0.03, b1 = 0.44, d = 316.8; p for each parameter < 2 × 10−16; r2 = 0.27. (B) Co-enrichment across non-YPD experiments from Harbison et al. [11]: b 0 = −0.004, b 1 = 0.09, d = 154.3; p for each parameter > 0.04; r2 = 0.004. (C) Co-enrichment across YPD experiments from Pokholok et al. [21]: b 0 = −0.01, b1 = 0.67, d = 148.4; p for each parameter < 2 × 10−16; r2 = 0.04. (D) ChIP-chip log2 fold enrichment for no-antibody control from Pokholok et al. [22]; b 0 = −0.008, b1 = −0.13, d = 504.2; p for each parameter < 4.4 × 10−10; r2 = 0.004. (E) ChIP-chip log2 fold enrichment for anti-rabbit IgG control from Pokholok et al. [23]: b 0 = −0.02, b1 = −0.15, d = 417.1; p for each parameter < 4.9 × 10−8; r2 = 0.004.