Figure 5From: L-carnitine and PPARα-agonist fenofibrate are involved in the regulation of Carnitine Acetyltransferase (CrAT) mRNA levels in murine liver cellsProtein complexes binding to RXRα binding site at the CrAT promoter. (A) EMSA. Nuclear extracts from TIB-73 cells supplemented with increasing concentrations of L-carnitine were incubated with γ-32P-labeled oligonucleotides representing the RXRα-binding site with anti-PPARα as indicated. (B) Histogramm of the denstitometrical scan of the EMSA presented in A. Values are mean ± SD, n = 3, ***p < 0.001 and *p < 0.05 vs. Corresponding supplementation levels are indicated with parentheses and asterisks on top to indicate the statistical significance of the p-values.Back to article page