Ambigraphic nucleic acid notations facilitate the manipulation and analysis of genetic data. With ambigraphic nucleic acid notations, complementary nucleic acids are represented by symbols that resemble one another when rotated 180 degrees. In the original Ambiscript notation, complementary nucleotides share inverted symbols (A). Consequently, rotating an entire sequence 180 degrees generates its complement (B). Furthermore, palindromes are visually identifiable as stretches of symbols that are unchanged when rotated around a center-point (C).