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Table 3 Effect of CG-1521 on cell growth of wild-type, gcn5Δ and gcn5 catalytic site mutant strains

From: High throughput screening identifies modulators of histone deacetylase inhibitors

OD600 fraction of control

  

CG-1521 [μM]

25

50

 

BY4741

WT

 

0.87 ± 0.04

†

BY4741

gcn5Δ

 

0.26 ± 0.18

†

DY2396

WT

0.88 ± 0.05

0.54 ± 0.06

*

DY5925

gcn5Δ

0.48 ± 0.06

0.15 ± 0.04

*

DY6603

gcn5(E173Q)

0.71 ± 0.09

0.21 ± 0.07

*

  1. Early-log phase BY4741 cells were treated with 25, 50 μM CG-1521 or vehicle control (DMSO) for 20 h. Cell growth was measured and the ratio of OD600 (CG-1521 cells/DMSO treated cells) was determined as described in Methods. The experiment was performed in 6 independent replicates (BY4741) or 7 independent replicates for DY2396/DY5925/DY6603 strains. The data represent the mean ± SD. (†,* Comparisons are considered significant if p < 0.05; within each treatment group all combinations are significantly different from each other).
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BMC Genomics

ISSN: 1471-2164

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