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Table 4 CG-1521 induces a budding index decrease in wild-type and gcn5Δ strains

From: High throughput screening identifies modulators of histone deacetylase inhibitors

Budding index analysis

Strain

Treatment

Budding index

  

2 h

4 h

WT

Control

0.50 ± 0.05

0.48 ± 0.03

50 μM CG-1521

0.30 ± 0.03*

0.16 ± 0.07*

5 μg/mL α-factor

0.10 ± 0.05*

0.25 ± 0.03*

gcn5Δ

Control

0.44 ± 0.04

0.44 ± 0.07

50 μM CG-1521

0.25 ± 0.04*

0.23 ± 0.07*

5 μg/mL α-factor

0.12 ± 0.04*

0.33 ± 0.07

  1. The budding index was determined as described in Methods. The data represent the mean ± SD of five independent biological replicates (*Comparisons are considered significant if p < 0.05 compared to control).
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BMC Genomics

ISSN: 1471-2164

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