From: Profile of whole blood gene expression following immune stimulation in a wild passerine
Uniprot-SwissProt annotation | RPKM | Â | Baggerley's test | Â | |||||
---|---|---|---|---|---|---|---|---|---|
Gene name | Accession | Identity % | Transcript name | LPS ± SD | Saline ± SD | Fold change | Test statistic | P-value | Known or possible functions |
GAL2 | P46158 | 91 | Gallinacin-2 (Beta-defensin 2) | 4.7 ± 2.3 | 0.02 ± 0.03 | 221.00 | 21.4 | <0.00001 | antimicrobial activity[55] |
AVID | P02701 | 70 | Avidin | 12.3 ± 5 | 0.2 ± 0.3 | 53.26 | 4.8 | <0.00001 | antimicrobial activity[56] |
SAA | P02740 | 73 | Serum amyloid A protein | 16.1 ± 8.3 | 0.6 ± 0.3 | 28.63 | 3.8 | 0.00017 | chemoattractant for immune cells, induction of pro-inflammatory cytokines and extracellular matrix degrading enzymes [53, 57] |
M126 | P28318 | 78 | Protein MRP-126 | 183 ± 76.8 | 24.1 ± 28.8 | 7.58 | 3.9 | 0.00011 | leukocyte chemoattractant, oxidant scavenging, antimicrobial activity[58] |
DNAJC12 | Q9UKB3 | 78 | DnaJ (Hsp40) homolog, subfamily C 12 | 10.4 ± 5.7 | 4.5 ± 2.4 | 2.30 | 3.7 | 0.00028 | co-chaperone for Hsp70 proteins [59] |
HPS5 | Q9UPZ3 | 80 | Ruby-eye protein 2 | 13.5 ± 6.2 | 6 ± 1.4 | 2.25 | 9.1 | <0.00001 | eumelanin synthesis [60] |
LY75 | O60449 | 56 | Lymphocyte antigen 75 (C-type lectin, CD205) | 62.9 ± 23.2 | 29.8 ± 12.1 | 2.14 | 5.0 | <0.00001 | |
GTF2H1 | P32780 | 90 | General transcription factor IIH subunit 1 | 69.8 ± 32.9 | 33.8 ± 7.9 | 2.07 | 7.5 | <0.00001 | part of DNA repair complex TFIIH [63] |
SLC25A6 | P12236 | 90 | ADP/ATP translocase 3 (ANT3) | 67.6 ± 15.7 | 32.9 ± 8 | 2.06 | 4.0 | 0.00008 | cellular energy metabolism, mediation of T-cell survival [64] |
ATP7A | P70705 | 90 | Copper-transporting ATPase 1 | 10.6 ± 1.6 | 5.1 ± 1.3 | 2.05 | 7.6 | <0.00001 | regulation of macrophage function and extracellular superoxide dismutase activity [65] |
DSCR3 | O14972 | 88 | Down syndrome critical region protein | 25.9 ± 2.7 | 12.9 ± 1.3 | 2.01 | 16.3 | <0.00001 | part of polymeric immunoglobulin receptor transporter retromere complex[66] |
SLC38A2 | Q5F468 | 89 | Sodium-coupled neutral amino acid transporter 2 (SNAT2) | 19.3 ± 7.9 | 49.1 ± 9.5 | −2.54 | −4.8 | <0.00001 | cell volume regulation, response to osmotic stress or amino acid depletion [67] |