Figure 2
From: Identification of cis-regulatory modules encoding temporal dynamics during development
Enrichment of the nuclear receptor – type GCNF motifs in cluster 12 gene set. A) ROC curve showing significant enrichment in putative NR binding sites (GCNF position weight matrix) among the 42 genes constituting cluster 12 (y axis) compared to a randomized set of 1000 Drosophila genes (x axis) using cisTargetX. The blue curve shows the detection of cluster 12 genes, the red line a random distribution, and the green curve shows a 2 sigma interval from random. B) Expression profile of the 10 best ranked genes. All genes display marked expression increase after 42 h after puparium formation (APF). C) The 10 genes are listed together with the size of the 6 tested CRMs (see Additional file 1: Table S2 and Additional file 1: Figure S2 for details).