Single-nucleotide polymorphisms (SNPs) identified in K. pneumoniae Kp13 compared to MGH 78578, NTUH-K2044 and 342 strains. (A) Total number of SNPs falling within non-coding and coding regions (CDSs) when compared with the three other strains. synon, synonymous. (B) Common SNPs falling within CDSs grouped by COG classification identified when compared with the strains NTUH-K2044 and MGH 78578. (C) Selected common SNPs falling within virulence- and resistance-related CDSs identified when compared with the NTUH-K2044 and MGH 78578 strains. MDR/DR, multidrug resistance/drug resistance; LPS, lipopolysaccharide. Numbers after the slash indicates the number of non-synonymous SNPs. COG classes single-letter abbreviations in panel B are: B (chromatin structure), C (energy production/conversion), D (cell division/chromosome partitioning), E (amino acid transport/metabolism), F (nucleotide transport/metabolism), G (carbohydrate transport/metabolism), H (coenzyme transport/metabolism), I (lipid transport/metabolism), J (translation/ribosomal structure), K (transcription), L (replication/recombination/repair), M (cell wall/membrane/envelope biogenesis), N (cell motility), O (posttranslational modification/protein turnover/chaperones), P (inorganic ion transport/metabolism), Q (secondary metabolite biosynthesis/transport/catabolism), R (general function prediction), S (function unknown), T (signal transduction), U (intracellular trafficking/secretion), V (defense mechanisms).