Figure 1

Comparative evolutionary analysis of the phosphomotifs. (A) Network diagram showing the sequence motif patterns and their conservation. The motifs were connected if the protein sequences that included the motifs were shared in more than 20% cases. The node colors that represent each motif are based on the conservation indices, ranging from blue to red. The network was created using Cytoscape. (B) Relationships between the conservation of motifs and the kinases that phosphorylated proteins with the motifs. The annotations of the kinase group names were determined on the basis of the known kinase–substrate relationships obtained from phosphorylation databases. Well-known motifs observed in several proteins were selected. (C) Increases in the interactions related to genes in phosphomotifs. The fold increase in the number of known interactions for genes in a motif was compared with that for random genes.