Figure 4

Gene networks triggered in human macrophages infected with different isolates of Mycobacterium avium . Cells have been incubated with M. avium subsp. avium 1794 (A), M. avium subsp. hominissuis VI101 (B) and M. avium subsp. hominissuis 1655 (C) for four hours. Blue hubs indicate up-regulation, yellow indicate down-regulation of the respective gene. The size of the gene name reflects the number of links to other genes in the network, and genes with < 5 genes are minimized. For this analysis the number of genes was reduced, in order to comply with the limitation of the IPA software, by increasing the stringency of the statistical analysis to FDR < 0.01 from FDR < 0.05.