The validation of MeDIP-seq data by bisulfite sequencing (BSP). A high methylated region obtained from MeDIP-seq data was selected randomly and its methylation pattern was profiled by BSP. The box indicated amplification regions. CpG dinucleotides are represented by circles on vertical bars. Each line represents an independent clone, and methylated CpGs are marked by filled circles, unmethylated CpGs by open circles.