Figure 3

Overview on the 20 significant pathways across all approaches (Figure 3A), in both permutation tests (Figure 3B) and just in original calculations (Figure 3 C). The figure presents the significance values for the 20 pathways (ordered clockwise according to decreasing significance as calculated by the Hypergeometric test), showing p-values < 0.05 for all three approaches. The further away from the middle the higher the significance scores (on a logarithmic scale). The grey shaded area in the middle corresponds to non-significant pathways. Significance values have been cut at 10^-5.