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Table 2 Genotypes for the p.W215X-mutation in PLD4 for 3,650 animals

From: A nonsense mutation in PLD4 is associated with a zinc deficiency-like syndrome in Fleckvieh cattle

Breed Animal group Samples Genotypes for p.W215X
AA AG GG
FV Affected calves 8 8 - -
  Dams of the calves 6 - 6 -
  Unaffected animals being homozygous for the disease-associated haplotype 3 - 2 1
  Animals carrying the disease-associated haplotype 169 - 100 69
  Animals not carrying the disease-associated haplotype 1,777 - - 1,777
  Animals with unknown haplotype status 1,125 - 51 1,074
HF Randomly selected animals 282 - - 282
BV Randomly selected animals 280 - - 280
  1. Genotypes for the nonsense-mutation (rs378824791) were obtained for 3,650 animals representing three different breeds (Fleckvieh (FV), Holstein-Friesian (HF) and Braunvieh (BV)) using a TaqMan® genotyping assay. The nonsense-mutation is homozygous in the affected calves only. The mutation does not segregate in Holstein-Friesian and Braunvieh. Note that animals carrying the disease haplotype were specifically added to Fleckvieh panel.