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Table 2 Genotypes for the p.W215X-mutation in PLD4 for 3,650 animals

From: A nonsense mutation in PLD4 is associated with a zinc deficiency-like syndrome in Fleckvieh cattle

Breed

Animal group

Samples

Genotypes for p.W215X

AA

AG

GG

FV

Affected calves

8

8

-

-

 

Dams of the calves

6

-

6

-

 

Unaffected animals being homozygous for the disease-associated haplotype

3

-

2

1

 

Animals carrying the disease-associated haplotype

169

-

100

69

 

Animals not carrying the disease-associated haplotype

1,777

-

-

1,777

 

Animals with unknown haplotype status

1,125

-

51

1,074

HF

Randomly selected animals

282

-

-

282

BV

Randomly selected animals

280

-

-

280

  1. Genotypes for the nonsense-mutation (rs378824791) were obtained for 3,650 animals representing three different breeds (Fleckvieh (FV), Holstein-Friesian (HF) and Braunvieh (BV)) using a TaqMan® genotyping assay. The nonsense-mutation is homozygous in the affected calves only. The mutation does not segregate in Holstein-Friesian and Braunvieh. Note that animals carrying the disease haplotype were specifically added to Fleckvieh panel.
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BMC Genomics

ISSN: 1471-2164

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