Power | | # of variants |
maxH
|
hPDT
|
hPDT-t
|
maxV
|
vPDT
|
vPDT-t
|
|---|
d%=0.5 | r%=1 | 23.10(sd=5.04) | 0.439 | 0.882 | 0.255 | 0.463 | 0.879 | 0.313 |
| | r%=0.8 | 22.21(sd=4.87) | 0.390 | 0.617 | 0.229 | 0.390 | 0.598 | 0.238 |
| | r%=0.5 | 21.60(sd=4.84) | 0.294 | 0.161 | 0.174 | 0.293 | 0.152 | 0.199 |
| | r%=0.2 | 20.93(sd=4.68) | 0.167 | 0.089 | 0.087 | 0.158 | 0.095 | 0.090 |
| | r%=0.05 | 20.17(sd=4.72) | 0.045 | 0.288 | 0.048 | 0.044 | 0.293 | 0.062 |
- Note: (1) “# of variants” indicates the mean and standard deviation (sd) values of the number of SNVs in a 20Kb test region on 1000 replicates (10 permutations for each replicate); (2) d% is the proportion of rare variants in the causal region to be causal; (3) r% is the proportion of causal variants increase risk.
- Abbreviations: maxH: maximal haplotype test; hPDT: haplotype-based pedigree disequilibrium test; hPDT-t: haplotype-based pedigree disequilibrium test with training data; maxV: maximal rare variant test; vPDT: variant-based pedigree disequilibrium test; vPDT-t: rare variant based pedigree disequilibrium test with training data.
