Figure 3

Distinct functional GO categories are enriched in Dex-regulated network Modules in BMM Ф . GO categories enriched among Dex-regulated genes in Modules 2 (A) and 1 (B) (p < 10^-3, hypergeometric test) were used to create GO terms similarity networks where the nodes represent GO gene sets and the edge length between two nodes is proportional to the fraction of shared genes in categories. Individual clusters were manually repositioned to simplify network layout and colored as indicated; the broad top GO terms are colored grey. The word tags were generated with WordTag Cytoscape plugin [29] to represent frequency-based semantic summary of words in GO category titles found in individual clusters and the size of the nodes is proportional to the number of genes in the respective GO gene set. (C) GO enrichment analysis of individual GO categories in Modules 1 and 2 relative to the mouse genome. The FDR-corrected p-values (hypergeometric test) are shown for each bar.