Figure 8
From: Glucocorticoid receptor coordinates transcription factor-dominated regulatory network in macrophages
Many LPS-downregulated genes encode Zn-finger proteins containing KRAB domains. (A) Domain overrepresentation analysis among LPS-suppressed genes (Clusters 10, 11 and 12) revealed a large number of Zn-finger proteins (COG 5048) that, in addition, contain KRAB, SCAN and BTB domains. The list of LPS-downregulated Zn-finger proteins is shown with KRAB, SCAN and BTB domains indicated as red, blue and green boxes, respectively. (B) The kinetics of LPS-mediated suppression of select genes encoding Zn-finger KRAB domain-containing proteins. BMMФ were treated with LPS for indicated time and the expression of indicated genes was assessed by RT-qPCR.