Figure 6

Distribution of the alternations of binding free energy (ΔΔG) are different between candidate causal MRESS SNPs and the total set of MRESS SNPs in 12 GWAS datasets. Red dotted line denotes the candidate causal MRESS SNPs while black solid line denotes the total set of MRESS SNPs in 12 GWAS datasets. ΔΔG in Figure 6A is calculated by single SNP while that in Figure 6B is calculated by haplotype. We can observe a decline of the peak near zero and rightward shift for candidate MRESS SNPs, which indicates the greater alternation of binding free energy are created.