Table 1 Functional annotation of significantly down and up-regulated genes (Separate analysis for 3500 YS epithelial genes)

13-17

n

348

458

1.56: endoplasmic reticulum; 1.54 plasma membrane organization; 1.44: ubiquitin ligase complex; 1.33: purine nucleotide binding;

2.59: macromolecular complex subunit organization; 2.16: cholesterol metabolic process; 1.65: chaperone mediated protein folding requiring cofactor; 1.51: cholesterol transport; 1.3: vacuole;

17-21

n

391

256

2.66: cytoskeletal part; 1.84: Intermediate filament protein; 1.74: actomyosin; 1.50: protein heterooligomerization; 1.25: lysosome

1.93: fatty acid metabolic process; 1.53: topological domain:Lumenal; 1.21: vitamin binding

15-19

n

269

389

2.53: macromolecule catabolic process; 2.46: GTP binding; 1.61: nucleotide binding; 1.56: zinc ion binding; 1.27: establishment of protein localization

2.24: sterol metabolic process; 1.76: protein dimerization activity; 1.74: extracellular region; 1.59: response to wounding; 1.43: lipid oxidation; 1.34: transmembrane receptor protein serine/threonine kinase signaling pathway; 1.28: growth factor binding; 1.22: Collagen triple helix repeat; 1.20: Fibrinogen

19-21

n

191

110

1.99: oxidation reduction; 1.59: keratin; 1.55: cholesterol metabolic process; 1.47: cofactor binding;

1.34: ossification; 1.25 membrane coat; 1.20: transmembrane region