Figure 5

Phylogenetic profile of metabolic enzymes and transporters. a) Phylogenetic profiles of E. falciformis genes were determined based on OrthoMCL clustering results and are shown separately for KEGG metabolic modules (groups of pathways). These KEGG annotations were derived with the KEGG Automatic Annotation Server KAAS and most metabolic enzymes are highly conserved. Bars for different modules are ordered by the proportion of novel genes at the genus Eimeria and subclass Coccidia level (see Figure 3). b) Genes annotated with Gene Ontology (GO) terms representing transporters (GO:0005215 “transporter activity” and descendants) and underrepresented in E. falciformis are compared for their representation in T. gondii and P. falciparum. Numbers of genes for a specific term were normalized with the total number annotations in a species and compared. Cells depict these normalized numbers of genes. Colors are additionally scaled by the total number of genes annotated for the term (row). c) Intersection of the Fructose and Mannose Metabolism, GPI-anchor and N-Glycan biosynthesis pathways. Colors are given for missing enzymes or enzymes with restricted phylogenetic profile.