Table 6 Associated network functions of candidate genes

1

26 s Proteasome, ADAMTS13, ATE1, BMPER, CAPN10, CD200R1, CENPF, Cg, COL12A1, collagen, CTTNBP2, DBF4, ENO1, ERK1/2, FGL2, GRM5, LDL, LRP2, LRP8, LRP, MKI67, NCF2, P38 MAPK, PDGF BB, Pkc(s), PLAU, PON2, Ppp2c, SACS, SLC6A4, SYNE1, TAS1R3, UBASH3A, Vegf

48

24

Cardiovascular Disease, Hematological Disease, Cardiac Infarction

2

ANKRD44, ANKRD52, API5, APOPT1, ATAD5, BMS1, C9orf114, CAMSAP2, CCDC115, CENPQ, CEP192, CGGBP1, CPVL, DDX26B, DNHD1, EMC1, ERAL1, ERCC6L, GTSE1, MTR, MTRR, PLK1, PPP6R1, PRRC1, RGPD5 (includes others), RNF169, RNF219, SIMC1, SPATA2L, STK10, STXBP4, TTC4, UBC, VRK3, ZNF292

26

15

Cell Cycle, DNA Replication, Recombination, and Repair, Developmental Disorder

3

ASPM, ATP6V0A2, ATP6V1E2, C15orf39, CCDC8, CHTF18, COPG1, DUS2L, EARS2, EPRS, FANCB, GEMIN5, HELB, INPP5B, KAT5, OGFOD2, PARS2, RNF168, SEC16A, SEPT3, SEPT7, SETX, SNX10, TMEM106B, TRIM68, UBC, USP30, USP34, USP35, USP40, USP48, USP27X, USP9Y, YEATS2, ZBTB8A

26

15

Developmental Disorder, Endocrine System Disorders, Hereditary Disorder

4

1810009J06Rik/Gm2663, ABCA4, ABCC6, ADCYAP1, BRCA1, BRIP1, Ca2+, CASC1, DNAH9, DPP7, DQX1, Gbp8, IFNG, IL4, KIF16B, KIF18A, LOC290071, MAPK8, MPHOSPH9, MPPE1, MYO16, NUFIP1, Pde, PDE1C, PDE7B, PPP1CA, PSEN1, Rb, RTDR1, SLAIN1, ST18, STAB2, TOP1MT, UTP, ZC3H12D

26

15

Cell Morphology, Cellular Function and Maintenance, Hair and Skin Development and Function

5

ABCD4, ABHD2, ADCK4, ANKRD10, AS3MT, C1QTNF4, CEP120, CLN6, CSPP1, DDX51, DLEC1, DMXL1, DPP7, EFHA1, FASTKD1, GAL3ST4, ILVBL, KRT12, KRT15, LRRC8A, MORC1, NR3C1, OGDHL, PEX1, SETD4, SPTLC2, SPTLC3, SPTSSB, STAT3, TEKT4, UBC, VPS13C, XRCC6, ZFYVE28, ZNF483

20

12

Lipid Metabolism, Small Molecule Biochemistry, Digestive System Development and Function

6

AIFM3, APP, BCL2L15, CASP3, DNAJB14, DNAJC4, DNAJC12, DNAJC19, HORMAD1, Hsp84-2, HSP90AB1, HSPB7, HSPD1, IARS2, IQCB1, KLHL32, MYLK4, NEK11, norepinephrine, OBSCN, OTC, RPGR, RUFY3, SMC3, TARP, TBX22, testosterone, TGM4, THAP4, TTPA, ULK4, UNC79, USH2A, YWHAQ, ZC2HC1A

17

11

Hereditary Disorder, Ophthalmic Disease, Neurological Disease

7

Act1, Akt, BRCA2, CBS, CD3, CENPJ, Ck2, Collagen type I, CRB1, CYP24A1, estrogen receptor, Immunoglobulin, INSRR, Jnk, LAG3, miR-101-3p (and other miRNAs w/seed ACAGUAC), MSLN, MZB1, NFkB (complex), NKTR, NR2C2, PI3K (complex), PIK3IP1, PIK3R6, PRKDC, Prl4a1, Psg16, SEC14L2, SNAPC4, Taok2, Tnfrsf22/Tnfrsf23, TRAF1-TRAF2-TRAF3, VTCN1, Zfp110/Zfp369, ZNF675

14

9

Cellular Response to Therapeutics, Cellular Assembly and Organization, DNA Replication, Recombination, and Repair