Figure 2

Differential expression of genes in Scnn1b -Tg lungs compared to WT. Unsupervised hierarchical clustering of the combined set of DEGs that survive the filtering criteria (FDR ≤ 0.05, fold-change ≥2) for WT versus Scnn1b-Tg for any time point; total genes represented = 84 (Additional file 2: Results file S1). Dark blue indicates lower expression levels and bright red indicates higher expression levels and each column represents the results of one microarray (n = 3 pools for each time point and genotype). DEGs appearing more than once reflect alternative probeset annotations on the Affymetrix microarrays. Scnn1b and Ttr differential gene expression reflects the overexpression from the transgenic construct used to generate the Scnn1b-Tg mice [9].