Table 10 Differentially regulated Gene Ontology groups from purified macrophages between WT and Scnn1b- Tg mice

UP-REGULATED

GO:0006936

GO:0030595

GO:0072593

GO:0009611

GO:0006954

Muscle contraction

Leukocyte chemotaxis

Reactive oxygen species metabolic process

Response to wounding

Inflammatory response

GO:0003012

GO:0032103

GO:0030595

GO:0032103

GO:0009611

Muscle system process

Positive regulation of response to external stimulus

Leukocyte chemotaxis

Positive regulation of response to external stimulus

Response to wounding

GO:0003007

GO:0060326

GO:0060326

GO:0030595

GO:0030595

Heart morphogenesis

Cell chemotaxis

Cell chemotaxis

Leukocyte chemotaxis

Leukocyte chemotaxis

GO:005500

GO:0050900

GO:0060445

GO:0006954

GO:0032103

Striated muscle cell development

Leukocyte migration

Branching involved in salivary gland morphogenesis

Inflammatory response

Positive regulation of response to external stimulus

GO:0060537

GO:0006935

GO:2000379

GO:0071621

GO:0071345

Muscle tissue development

Chemotaxis

Positive regulation of reactive oxygen species metabolic process

Granulocyte chemotaxis

Cellular response to cytokine stimulus

GO:0055001

GO:0071621

GO:0032103

GO:0002687

GO:0034097

Muscle cell development

Granulocyte chemotaxis

Positive regulation of response to external stimulus

Positive regulation of leukocyte migration

Response to cytokine stimulus

GO:0043062

GO:0002687

GO:2000147

GO:0002685

GO:0042330

Extracellular structure organization

Positive regulation of leukocyte migration

Positive regulation of cell motility

Regulation of leukocyte migration

Taxis

GO:0051216

GO:0042330

GO:0050921

GO:0002253

GO:0050714

Cartilage development

Taxis

Positive regulation of chemotaxis

Activation of immune response

Positive regulation of protein secretion

GO:0031032

GO:0050795

GO:2000377

GO:0002757

GO:0006935

Actomyosin structure organization

Regulation of behavior

Regulation of reactive oxygen species metabolic process

Immune response-activating signal transduction

Chemotaxis

GO:0030239

GO:0048520

GO:0002690

GO:0042330

GO:0002685

Myofibril assembly

Positive regulation of behavior

Positive regulation of leukocyte chemotaxis

Taxis

Regulation of leukocyte migration

DOWN-REGULATED

GO:0007186

GO:0006996

GO:0007059

NONE*

NONE*

G-protein coupled receptor signaling pathway

Organelle organization

Chromosome segregation

GO:0034470

GO:0007059

GO:0000819

ncRNA processing

Chromosome segregation

Sister chromatid segregation

GO:0006364

GO:0000819

GO:0000070

rRNA processing

Sister chromatid segregation

Mitotic sister chromatid segregation

GO:0016072

GO:0006261

GO:0032465

rRNA metabolic process

DNA-dependent DNA replication

Regulation of cytokinesis

GO:0034660

GO:0006302

GO:0006281

ncRNA metabolic process

Double-strand break repair

DNA repair

GO:0042254

GO:0000070

GO:0032508

Ribosome biogenesis

Mitotic sister chromatid segregation

DNA duplex unwinding

GO:0045076

GO:0007051

GO:0051983

Regulation of interleukin-2 biosynthetic process

Spindle organization

Regulation of chromosome segregation

GO:0008033

GO:0051225

GO:0007051

tRNA processing

Spindle assembly

Spindle organization

NONE*

GO:0008608

GO:0000280

Attachment of spindle microtubules to kinetochore

Nuclear division

GO:0000724

GO:0007067

Double-strand break repair via homologous recombination

Mitosis