Table 3 Developmentally regulated Gene Ontology groups for whole lung in WT and Scnn1b- Tg mice

UP-REGULATED

GO:0007608

GO:0007608

GO:0030198

GO:0007067

GO:0006959

GO:0006959

Sensory perception of smell

Sensory perception of smell

Extracellular matrix organization

Mitosis

Humoral immune response

Humoral immune response

GO:0007606

GO:0007606

GO:0043062

GO:0000280

GO:0048002

GO:0019882

Sensory perception of chemical stimulus

Sensory perception of chemical stimulus

Extracellular structure organization

Nuclear division

Antigen processing and presentation of peptide antigen

Antigen processing and presentation

GO:0007600

GO:0007600

GO:0021988

GO:0007059

GO:0002455

GO:0002253

Sensory perception

Sensory perception

Olfactory lobe development

Chromosome segregation

Humoral immune response mediated by circulating immunoglobulin

Activation of immune response

GO:0019236

GO:0019236

GO:0030199

GO:0048285

GO:0072376

GO:0050778

Response to pheromone

Response to pheromone

Collagen fibril organization

Organelle fission

Protein activation cascade

Positive regulation of immune response

GO:0009263

GO:0007186

GO:0031589

GO:0051301

GO:0006956

GO:0048002

Deoxyribonucleotide biosynthetic process

G-protein coupled receptor signaling pathway

Cell-substrate adhesion

Cell division

Complement activation

Antigen processing and presentation of peptide antigen

GO:0007186

GO:0002861

GO:0071526

GO:0000278

GO:0002474

GO:0072376

G-protein coupled receptor signaling pathway

Regulation of inflammatory response to antigenic stimulus

Semaphorin-plexin signaling pathway

Mitotic cell cycle

Antigen processing and presentation of peptide antigen via MCH class I

Protein activation cascade

GO:0033108

GO:0002675

GO:0007155

GO:0007051

GO:0019882

GO:0006956

Mitochondrial respiratory chain complex assembly

Positive regulation of acute inflammatory response

Cell adhesion

Spindle organization

Antigen processing and presentation

Complement activation

GO:0009262

GO:0050877

GO:0002040

GO:0031023

GO:0006958

GO:0002455

Deoxyribonucleotide metabolic process

Neurological system process

Sprouting angiogenesis

Microtubule organizing center organization

Complement activation classical pathway

Humoral immune response mediated by circulating immunoglobulin

GO:0006270

GO:0050715

GO:0090132

GO:0007052

GO:0002449

GO:0002684

DNA replication initiation

Positive regulation of cytokine secretion

Epithelial migration

Mitotic spindle organization

Lymphocyte mediated immunity

Positive regulation of immune system process

GO:0032981

GO:0046146

GO:0021772

GO:0051297

GO:0017144

GO:0002478

Mitochondrial respiratory chain complex I assembly

Tetrahydrobiopterin metabolic process

Olfactory bulb development

Centrosome organization

Drug metabolic processes

Antigen processing and presentation of exogenous peptide antigen

DOWN-REGULATED

GO:0007265

GO:0051056

GO:0044364

GO:0008299

GO:0007067

GO:0007067

Ras protein signal transduction

Regulation of small GTPase mediated signal transduction

Disruption of cells of other organism

Isoprenoid biosynthetic process

Mitosis

Mitosis

GO:0051056

GO:0007265

GO:0031640

NONE*

GO:0000280

GO:0000280

Regulation of small GTPase mediated signal transduction

Ras protein signal transduction

Killing of cells of other organism

Nuclear division

Nuclear division

GO:0046578

GO:0046578

GO:0051818

GO:0048285

GO:0048285

Regulation of Ras protein signal transduction

Regulation of Ras protein signal transduction

Disruption of cells of other organism involved in symbiotic interaction

Organelle fission

Organelle fission

GO:0007266

GO:0007266

GO:0051883

GO:0007059

GO:0007059

Rho protein signal transduction

Rho protein signal transduction

Killing of cells in other organism involved in symbiotic interaction

Chromosome segregation

Chromosome segregation

GO:0035295

GO:0016568

GO:0006953

GO:0051301

GO:0051301

Tube development

Chromatin modification

Acute phase response

Cell division

Cell division

GO:0010631

GO:0016569

GO:0050829

GO:0006323

GO:0000278

Epithelial cell migration

Covalent chromatin modification

Defense response to Gram-negative bacterium

DNA packaging

Mitotic cell cycle

GO:0090130

GO:0016570

GO:0002886

GO:0000278

GO:0006323

Tissue migration

Histone modification

Regulation of myeloid leukocyte mediated immunity

Mitotic cell cycle

DNA packaging

GO:0090132

GO:0007507

GO:0051873

GO:0000819

GO:0071103

Epithelium migration

Heart development

Killing by host of symbiont cells

Sister chromatid segregation

DNA conformation change

GO:0060562

GO:0046777

GO:0051852

GO:0000070

GO:0022402

Epithelial tube morphogenesis

Protein autophosphorylation

Disruption by host of symbiont cells

Mitotic sister chromatid segregation

Cell cycle process

GO:0035239

GO:0072358

GO:0031424

GO:0071103

GO:0034470

Tube morphogenesis

Cardiovascular system development

Keratinization

DNA conformation change

ncRNA processing