Performance comparison and evaluation of ADTEx predictions against data from Affymetrix SNP 6.0 genotyping arrays. (a) Comparison of predictions on sample OV12. Copy number predictions by ASCAT (top panel), copy number predictions by ADTEx (second panel), LOH predictions by ASCAT (third panel) and LOH predictions by ADTEx (bottom panel). The top two panels show the exon level depth of coverage ratios and each colour represents the predicted copy number, while bottom two panels show the tumour BAF of heterozygous loci in the matched normal sample with colours representing the predicted LOH status. (b) Performance metrics of ADTEx copy number predictions computed as accuracy, precision, sensitivity and specificity and (c) performance metrics of ADTEx LOH predictions on all samples.