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Table 1 Detoxification protein families investigated in this work, divided into functional categories

From: Metagenomics reveals that detoxification systems are underrepresented in marine bacterial communities

Protein family Pfam name Number of reads GOS Initial Number of reads GOS Reciprocal GOS Reciprocal (%) Genomes average (genes/genome) Genomes CV (%)
Metal resistance       
Arsenate reductase ArsC 993 853 85.9 1.1 108
Divalent ion tolerance protein CutA1 511 511 100 0.4 127
Copper resistance protein CopC CopC 472 426 90.3 0.3 206
Multicopper oxidase Cu-oxidase_3 435 313 72 0.7 154
Copper transporter CutC 258 258 100 0.2 182
Tellurite resistance protein TehB 2956 244 8.3 0.2 206
Arsenical pump membrane protein ArsB 177 19 10.7 0.3 218
Cadmium binding protein YodA 1 0 0 0.0 492
Transporters       
Major facilitator family MFS_1 22627 19301 85.3 23.1 108
ACR transporter ACR_tran 10591 10337 97.6 4.4 126
Multi antimicrobial extrusion protein MatE 5164 4308 83.4 2.2 120
Efflux pump HlyD 4048 2693 66.5 6.9 121
Small Multidrug Resistance protein Multi_Drug_Res 2194 2097 95.6 1.0 134
C4-dicarboxylate transporter C4dic_mal_tran 71 71 100 0.3 173
Oxidative stress       
Peroxiredoxin AhpC-TSA 14009 7397 52.8 3.5 91
Thioredoxin Thioredoxin 8221 4668 56.8 2.7 67
Redoxin Redoxin 13178 4410 33.5 1.7 108
Peroxidase peroxidase 3067 3065 99.9 0.4 154
Glutathione peroxidase GSHPx 2380 2218 93.2 0.6 131
Superoxide dismutase Sod_Fe_C 935 796 85.1 0.9 78
Catalase Catalase 91 88 96.7 0.8 146
Other detoxification systems       
Bacitracin resistance protein BacA 2803 2799 99.9 0.8 73
Organic solvent tolerance protein OstA_C 1094 1086 99.3 0.4 121
Fusaric acid resistance protein FUSC 67 65 97 0.8 205
Di-haem cytochrome c peroxidase CCP_MauG 606 582 96 0.5 211
Beta-lactamase Beta-lactamase 5196 4985 95.9 2.6 149
NADH oxidase Oxidored_FMN 2598 2349 90.4 1.9 130
Penicillin binding transpeptidase Transpeptidase 9702 8379 86.4 2.1 72
Multiple antibiotic resistance operon repressor MarR 2949 2078 70.5 5.8 128
MAATS-type multidrug transcriptional repressor TetR_C_2 21 12 57.1 0.1 343
NADPH-dependent FMN reductase FMN_red 2222 1076 48.4 2.5 110
Control protein families       
Elongation factor TS EF_TS 2780 2734 98.3 0.8 49
DNA polymerase A DNA_pol_A 5372 4973 92.6 0.9 55
RNA polymerase rpoB RNA_pol_Rpb2_6 5847 5106 87.3 1.0 9
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