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Table 4 The number of SNPs with P -value <1 × 10 -5 based on GxE GWAS in GOLDN 1

From: Genome-wide interaction of genotype by erythrocyte n-3 fatty acids contributes to phenotypic variance of diabetes-related traits

  Without GxE    With GxE   
Trait2 Main effect E factor GxE3 Main effect GxE interaction Total for main and GxE
HOMA-IR 5 DPA S 11 9 20
  ALA NS 3 3 6
Fasting insulin 7 DPA S 12 21 32
  ALA NS 6 6 12
Fasting glucose 9 AA/ (EPA + DHA) S 25 36 57
  ALA NS 2 1 3
Adiponectin 18 AA/ EPA S 33 13 44
  n-6 PUFA NS 2 7 9
  1. 1PUFA, polyunsaturated fatty acid; DHA, docosahexaenoic acid; EPA, eicosapentaenoic acid; DPA, docosapentaenoic acid; ALA, alpha -linolenic acid; AA, arachidonic acid; GWAS, genome-wide association study.
  2. 2For all these traits, GWAS and GxE GWAS were adjusted for age, sex, body mass index, study center, energy intake, kinship, and population structure.
  3. 3The E factor has a significant (S) or non-significant (NS) GxE variance contribution to the total phenotypic variance of either diabetes-related trait based on GxE GWAS.