Figure 3

Comparison of CNV rates between the miPSCs induced by different reprogramming methods. (A) The comparison of CNV numbers between O_0.5 and O_1.5 miPSC lines. This difference is statistically significant (p-value = 0.030, Mann–Whitney U test with the exact significance). (B) The comparison of CNV numbers between OKS_0.5 and OKS_1.5 miPSC lines (Mann–Whitney U test with the exact significance). (C) The combinational analysis of (A) and (B). A significant difference of CNV numbers between high and low reprogramming factor dosages was found (p-value = 0.008, ANOVA test for two-factor analysis). (D) The comparison of CNV numbers between the methods using diverse reprogramming factors with balanced dosages (Mann–Whitney U test with the exact significance). The CNVs are significantly less in the miPSCs of XYZK_0.5 than in those of O_0.5 (p-value = 0.043) and OKS_0.5 (p-value = 0.023).