Dual transcriptional profiling of mice and Toxoplasma gondii during acute and chronic infection

Pittman, Kelly J; Aliota, Matthew T; Knoll, Laura J

doi:10.1186/1471-2164-15-806

BMC Genomics

Table 4 T. gondii DEGs that were more abundant >5 fold in chronic vs acute infection

From: Dual transcriptional profiling of mice and Toxoplasma gondii during acute and chronic infection

Gene ID	Description	Fold change: chronic/acute
TGME49_224630	zinc finger (CCCH type) protein	86
TGME49_259020	bradyzoite antigen BAG1 (BAG1)	48
TGME49_202020	DnAK-TPR	44
TGME49_278080	Toxoplasma gondii family A protein (SUSA-1)	32
TGME49_291040	lactate dehydrogenase LDH2 (LDH2)	31
TGME49_200250	microneme protein MIC17A (MIC17A)	29
TGME49_260190	microneme protein MIC13 (MIC13)	29
TGME49_267680	microneme protein MIC12 (MIC12)	28
TGME49_262970	hypothetical protein	26
TGME49_245530	hypothetical protein	26
TGME49_204420	oocyst wall protein OWP1 (OWP1)	23
TGME49_318880	hypothetical protein	18
TGME49_289370	hypothetical protein	18
TGME49_207210	hypothetical protein	18
TGME49_209985	cAMP-dependent protein kinase	18
TGME49_309930	melibiase subfamily protein	17
TGME49_320260	hypothetical protein	15
TGME49_293780	hypothetical protein	14
TGME49_216140	tetratricopeptide repeat-containing protein	14
TGME49_280570	SAG-related sequence SRS35A (SRS35A)	13
TGME49_320190	SAG-related sequence SRS16B (SRS16B)	11
TGME49_250940	hypothetical protein	11
TGME49_306620	AP2 domain transcription factor AP2IX-9 (AP2IX9)	11
TGME49_209755	hypothetical protein	11
TGME49_207160	SAG-related sequence SRS49D (SRS49D)	10
TGME49_202030	hypothetical protein	10
TGME49_312600	heat shock protein HSP21 (HSP21)	9
TGME49_290000	hypothetical protein	9
TGME49_256760	pyruvate kinase PyK1 (PYKI)	8
TGME49_225290	GDA1/CD39 (nucleoside phosphatase)	7
TGME49_269670	hypothetical protein	7
TGME49_253330	Rhoptry kinase family protein	7
TGME49_225540	hypothetical protein	7
TGME49_282130	hypothetical protein	6
TGME49_207710	phosphatidylinositol synthase	6
TGME49_205680	hypothetical protein	6
TGME49_276200	hypothetical protein	6
TGME49_283780	glucose-6-phosphate isomerase GPI (GPI)	6
TGME49_285980	glucosephosphate-mutase GPM1 (GPM1)	6
TGME49_264420	lipoprotein	6
TGME49_226420	peptidase family M3 protein	6
TGME49_290980	glycine C-acetyltransferase	6
TGME49_275320	penicillin amidase	5
TGME49_201840	aspartyl protease ASP1 (ASP1)	5
TGME49_246080	NAD dependent epimerase/dehydratase	5
TGME49_222370	SAG-related sequence SRS13 (SRS13)	5
TGME49_315760	AP2 domain transcription factor AP2XI-4 (AP2XI4)	5
TGME49_294400	hypothetical protein	5
TGME49_215910	hypothetical protein	5
TGME49_224950	calcium-dependent protein kinase CDPK5 (CDPK5)	5
TGME49_256060	nucleosome assembly protein (nap) protein	5
TGME49_205750	histone deacetylase complex subunit Sin3 (SIN3)	5
TGME49_253320	hypothetical protein	15*
TGME49_254330	lipase	16*
TGME49_309790	hypothetical protein	16*
TGME49_269300	lipase	17*
TGME49_223258	hypothetical protein	17*
TGME49_207875	GCC2 and GCC3 domain-containing protein	17*
TGME49_269020	hypothetical protein	18*
TGME49_261200	TBC domain-containing protein	18*
TGME49_254150	hypothetical protein	18*
TGME49_306500	hypothetical protein	18*
TGME49_245440	hypothetical protein	19*
TGME49_207980	PIG-P protein	19*
TGME49_220150	50S ribosomal protein L16	19*
TGME49_320720	hypothetical protein	19*
TGME49_268765	hypothetical protein	19*
TGME49_260530	Sel1 repeat-containing protein	22*
TGME49_269320	hypothetical protein	23*
TGME49_215300	hypothetical protein	24*
TGME49_308096	rhoptry kinase family protein	25*
TGME49_240470	hypothetical protein	25*
TGME49_460810	ribosomal RNA	25*
TGME49_310045	hypothetical protein	26*
TGME49_224180	hypothetical protein	26*
TGME49_205210	hypothetical protein	26*
TGME49_204040	hypothetical protein	27*
TGME49_297850	Branched-chain-amino-acid aminotransferase	27*
TGME49_215130	adaptor-related protein complex 3	27*
TGME49_207600	tubulin/FtsZ family, GTPase	27*
TGME49_200230	microneme protein MIC17C (MIC17C)	28*
TGME49_231125	hypothetical protein	30*
TGME49_219610	hypothetical protein	31*
TGME49_240480	cpw-wpc domain-containing protein	31*
TGME49_315520	calcium binding egf domain-containing protein	32*
TGME49_232430	hypothetical protein	33*
TGME49_244412	hypothetical protein	33*
TGME49_223855	RNA recognition motif-containing protein	35*
TGME49_260325	hypothetical protein	37*
TGME49_234625	EGF family domain-containing protein	37*
TGME49_255460	hypothetical protein	40*
TGME49_321710	IgA-specific serine endopeptidase	43*
TGME49_319090	proteasome maturation factor ump1 protein	50*
TGME49_209090	hypothetical protein	52*
TGME49_210682	hypothetical protein	53*
TGME49_213480	hypothetical protein	53*
TGME49_210095	hypothetical protein	57*
TGME49_313890	hypothetical protein	58*
TGME49_271450	hypothetical protein	59*
TGME49_321700	hypothetical protein	80*
TGME49_219742	hypothetical protein	87*
TGME49_266600	Kazal-type serine protease inhibitor	89*
TGME49_257970	hypothetical protein	89*
TGME49_258370	rhoptry kinase family protein ROP28 (ROP28)	103*
TGME49_295662	hypothetical protein	110*
TGME49_278882	GDA1/CD39 (nucleoside phosphatase)	113*
TGME49_264150	hypothetical protein	141*

First column is the gene number from ToxoDB.org. The far right column is the fold change calculated from the average FPKM value from chronic infection divided by the average FPKM value from acute infection. * in the fold change column indicates the average FPKM value during acute infection was 0, and could not be divided by the average FPKM value in chronic infection. A p-value and q-value of <0.05 was considered to be statistically significant and only genes that met these standards were included on this table.

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ISSN: 1471-2164

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