High dose ionizing radiation regulates micro RNA and gene expression changes in human peripheral blood mononuclear cells

Table 1 Identification of miRNA 3’UTR binding sites in the set of down-regulated mRNAs

miRNA	Non-irradiated 20 h	Irradiated 20 h	p-value	Target genes	Seed counts
miR-887	−0.06	7.83	5.46E-05	76	87
miR-1306	−0.06	7.31	4.13E-04	18	18
miR-1180	−0.06	6.71	4.25E-04	79	87
miR-1268	3.71	6.46	4.93E-03	199	272
miR-371-5p	7.07	8.55	ns.	79	87
miR-630	6.92	8.28	ns.	383	709

1018 down-regulated mRNAs 20 hours after irradiation with FC > 1.0 were used for Sylamer analysis. p-value: difference between non-irradiated and irradiated PBMCs based on microarray expression data; target genes: number of genes targeted by the miRNA; seed counts: number of unique seeding regions in the given miRNA.

ISSN: 1471-2164