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Figure 2 | BMC Genomics

Figure 2

From: The highly polymorphic CYP6M7 cytochrome P450 gene partners with the directionally selected CYP6P9a and CYP6P9b genes to expand the pyrethroid resistance front in the malaria vector Anopheles funestus in Africa

Figure 2

Transcriptional profiling of resistant populations. A) Summary of probes differentially regulated in each of the 3 countries. The Venn diagrams show the number of probes significantly (P < 0.01) up- or down-regulated (FC > 2) in each country as well as the commonly expressed probes. Upward arrows indicate up-regulated probes, and downward arrows represent down-regulated probes. B) Relative expression of the three main detoxification genes (CYP6P9a, CYP6P9b and CYP6M7) by microarray between the three countries (based on probes with highest expression); C) Differential expression of 15 genes up-regulated between permethrin-resistant (R) and -susceptible FANG (S) mosquitoes in the Mozambican (MZ), Malawian (ML) and Zambian field populations (ZB). Fold-change for CYP6M7 was obtained from the average of three independent primer pairs. Error bars represent standard deviation (N = 3). The presence of * on top of the three fold changes for each gene indicates a statistically significant over-expression in all locations compared to the FANG susceptible strain. "ns" is added when the difference was not significant. D) Tissue-specific expression of CYP6P9a, CYP6P9b and CYP6M7 in field permethrin-resistant female An. funestus mosquitoes.

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BMC Genomics

ISSN: 1471-2164

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