Figure 2

Frequency and CNA coverage length distribution of CTLP regions in the genome. (A) Red and blue bars indicate CTLP frequency in percent of all CTLP and chromosome size in megabases, respectively. (B) Local distribution of CTLP regions among diagnostic groups. Each row represents a cancer type and each column represents a chromosome. We use a black-to-yellow gradient for representing CTLP frequencies ranging from lowest to highest, normalized for each row. The numbers in brackets indicate the number of cases. Groups with at least 5 CTLP cases are shown. (C) Distribution of CTLP events as fractions of the affected genomes, represented as density plots for common cancer types. The fractions for each sample have been calculated as sum of genome bases chromosomes 1–22, divided by the genomic length of CTLP regions as identified through our scanning approach.