Figure 7From: Comparative DNA methylome analysis of endometrial carcinoma reveals complex and distinct deregulation of cancer promoters and enhancersProposed model for loss of tissue identity during carcinogenesis associated with epigenetic alterations at enhancers. Left: Normal DNA methylation at enhancers mediates tissue-specific gene silencing and activation in normal cells. Right: DNA methylation alteration at enhancers in cancer cells induces abnormal regulation and subsequent changes in expression of tissue-specifically silenced or activated genes, leading to loss of tissue identity.Back to article page