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Table 1 Examples of significantly enriched GO annotation for the list of morphine-responsive genes

From: Whole-genome expression profile in zebrafish embryos after chronic exposure to morphine: identification of new genes associated with neuronal function and mu opioid receptor expression

Enriched GO annotation De‐regulation Up‐regulation Down‐regulation
No. genes P value No. genes P value Genes No. genes P value Genes
Oxidation‐reduction process (GO:0055114) 52 3.4E + 10 18 0.013 acox1, cyp11a1, cyp26b1, cyp27a1.4, d2hgdh, gapdhs, 34 3.7E + 10 adh8b, aldh18a1, cp, cyp2aa4, dao.1, dhfr, dhrs13b, mdh1b, phyhd1, ptgr1, sepx1a
Proteolysis (GO:0006508) 37 0.049 11   ube2d2 27 0.036 f7, rad23b, spcs2, uchl5, vsg1
Macromolecule catabolic process (GO:0009057) 23 0.003 4   ube2d2 19 4.3E + 12 ctbs. LOC553461, rad23b, uvsg1
Monosaccharide metabolic process (GO:0005996) 18 6.8E + 08 11 3.8E + 09 aldocb,galk2, gapdhs, gpia 7 0.050 mdh1b, pklr
DNA metabolic process (GO:0006259) 17 0.080 5   mlf1, mphosph8 12 0.054 orc4, rad23b
Protein catabolic process (GO:0030163) 16 0.002     16 0.002 LOC553461, rad23b, uchl5, vsg1
Macromolecular complex assembly (GO:0065003) 16 0.003 7 0.044 h1fx 9 0.065 fgg, tubb5
Generation of precursor metabolites and energy (GO:0006091) 15 0.012 9 0.006 aldocb, gapdhs, gpia 6   mdh1b, pklr
Homeostatic process (GO:0042592) 15 0.025 5   fth1 10 0.060  
Posttranslational modification. protein turnover. chaperones 13 0.005 1    12 1.9E + 12  
Protein complex assembly (GO:0006461) 12 0.005 4    8 0.024 fgg, tubb5
Lipid metabolism 9 0.005 4 0.087 acsl1, acsl5 5 0.072  
Response to wounding (GO:0009611) 9 0.010 3   cxcl12a 6 0.042 f7, fgg
Proteasome complex (GO:0000502) 8 5.1E + 11     8 5.1E + 11  
Blood coagulation (GO:0007596) 7 7.1E + 11 2   tfpia 5 0.005 f7,fgg
Positive regulation of apoptosis (GO:0043065) 7 0.010 3   bnip4 4   
Striated muscle cell development (GO:0055002) 6 0.060 3   cxcl12a 3   tnnt2a
Intermediate filament cytoskeleton (GO:0045111) 5 0.043 1   cyp27a1.4 4 0.043 krt23
Notch signaling pathway (GO:0007219) 5 0.072 2   dlc 3   vsg1
ribosomic RNA processing (GO:0006364) 5 0.086     5 0.021  
Secondary metabolites biosynthesis. transport. and catabolism 5 0.044 5 0.044 cyp11a1. cyp26b1. cyp51    
protein processing (GO:0016485) 4 0.036 1    3   spcs2
serine family amino acid metabolic process (GO:0009069) 4 0.065 2   gcshb 2   dhfr
  1. The complete results of the Gene Ontology (GO) analysis are presented in Additional file 3.