Figure 6
pyrene-induced DNA adducts and gene expression profiles in target and non-target organs for carcinogenesis in mice
The 21 miRNAs significantly modulated in 6 female mouse organs. The mice received 5 daily doses of 125 mg/kg b.wt/day of BaP by oral gavage. The numbers represent fold change in expression relative to control organs (red, up-regulated; green, down-regulated). The deregulated miRNAs were filtered by relative expression ratios with fold-change cut-offs of 1.5 (t-test p < 0.05).