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Table 1 Estimate of the type I error rate

From: A flexible Bayesian method for detecting allelic imbalance in RNA-seq data

Model

Type I error rate

Binomial

4.9%

NB: p=D N A

3.5%

PG: Ï•=D N A

3.8%

PG: q=1/2

3.2%

  1. Allele-specific counts from DNA and RNA-seq data were simulated with no bias and no allelic imbalance for three replicates each of 10,000 exonic regions and analyzed using the binomial exact test, the random bias parameter NB and PG models that use DNA controls and the PG model with fixed bias parameter, q = 1/2. Even when there is no bias, the Bayesian models have better performance than a binomial exact test.
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BMC Genomics

ISSN: 1471-2164

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