Effect of candidate gene knockdown on 10 cancer related pathways in SU86 cells. The Cancer Cignal Reporter assay was used to determine the effect of candidate gene knockdown on 10 cancer related signaling pathways. Each column indicates relative luciferase activity of the transcription factor-transfected SU86 cells. The x-axis indicates individual TF dependent cancer signaling pathways. * indicates P < 0.05 as compared to control cells, while ** indicates P < 0.01.