Gene symbol | Selection strategy | Cytotoxicity validation in cancer cell lines | |||
---|---|---|---|---|---|
SNP vs. IC50 | Integrated analysis | Both SU86 and MDA231 | Either THP-1 or BDCM | ||
SNP Location | P < 10-4 | SNP vs. Exp P < 10-4 | (cancer cell lines) | (leukemia cell lines) | |
Exp vs. IC50 P <10-4 | |||||
PIGB | Intron/coding/5UTR/3UTR | Gem | Gem | Yes | NP |
C3orf23 | 5UTR/upstream | Gem | Gem | No | NP |
ZADH2 | Gem | Yes | NP | ||
ARHGEF12 | Gem | No | NP | ||
DPP7 | Gem | No | NP | ||
PSME3 | Gem | Yes | NP | ||
NIPSNAP3B | Intron/5UTR | Gem | No | NP | |
PIK3R1 | Flanking_5UTR/3UTR | Gem | No | NP | |
DOK6 | Intron | Gem | Yes | NP | |
TGFBI | Flanking_5UTR | Gem | Yes | NP | |
UNC13C | AraC | No | No | ||
C14orf169 | AraC | Yes | NP | ||
MAP4K4 | AraC | No | NP | ||
URB2 | Downstream | AraC | No | No | |
TUSC3 | Intron/5UTR/3UTR | AraC | Yes | No | |
LARS2 | 5UTR | AraC | Yes | No | |
RIS1 (TMEM158) | 5UTR | AraC | Yes | Yes | |
IGSF4 (CADM1) | Intron/downstream/3UTR | AraC | No | No | |
LNX2 | Intron/5UTR/3UTR | AraC | Yes | No | |
SMC2 | 3UTR | AraC | Yes | Yes | |
PLD5 | Intron | Both | No | NP | |
GPR98 | Intron | Both | No | No | |
HLA-DRA | Intron/3UTR | Both | Yes | No | |
ZNF215 | Flanking_5UTR/3UTR/coding | Both | No | No | |
CABLES1 | Both | No | No |