Table 5 The top seven SNPs in PIGB that were associated with gemcitabine cytotoxicity and its expression in LCLs by integrated analysis
SNP | Gene | SNP vs. IC50 | SNP vs. Expression | Expression vs. IC50 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 rsID | Chr | Position | Region | MAF |  Probeset | Gene symbol |  Chr | R value |  P value |  R value |  P value |  R value |  P value |
rs2290344 | 15 | 53407088 | Coding | 0.253 | 205452_at | PIGB | 15 | 0.339 | 1.75E-05 | −0.340 | 1.06E-08 | −0.212 | 5.31E-03 |
rs2290344 | 15 | 53407088 | Coding | 0.253 | 242760_x_at | PIGB | 15 | 0.339 | 1.75E-05 | −0.301 | 4.81E-07 | −0.294 | 8.98E-05 |
rs4774760 | 15 | 53376504 | 5′-upstream | 0.416 | 205452_at | PIGB | 15 | 0.326 | 3.63E-05 | −0.283 | 2.48E-06 | −0.212 | 5.31E-03 |
rs4774760 | 15 | 53376504 | 5′-upstream | 0.416 | 242760_x_at | PIGB | 15 | 0.326 | 3.63E-05 | −0.240 | 6.85E-05 | −0.294 | 8.98E-05 |
rs8024695 | 15 | 53426597 | Intron | 0.285 | 205452_at | PIGB | 15 | 0.321 | 5.00E-05 | −0.326 | 4.60E-08 | −0.212 | 5.31E-03 |
rs8024695 | 15 | 53426597 | Intron | 0.285 | 242760_x_at | PIGB | 15 | 0.321 | 5.00E-05 | −0.282 | 2.56E-06 | −0.294 | 8.98E-05 |
rs12050587 | 15 | 53414820 | Intron | 0.450 | 205452_at | PIGB | 15 | 0.305 | 1.23E-04 | −0.246 | 4.54E-05 | −0.212 | 5.31E-03 |
rs28668016 | 15 | 53398725 | 5′-UTR | 0.365 | 205452_at | PIGB | 15 | 0.304 | 1.31E-04 | −0.346 | 5.97E-09 | −0.212 | 5.31E-03 |
rs28668016 | 15 | 53398725 | 5′-UTR | 0.365 | 242760_x_at | PIGB | 15 | 0.304 | 1.31E-04 | −0.274 | 5.28E-06 | −0.294 | 8.98E-05 |
rs11636687 | 15 | 53392444 | 5′-upstream | 0.421 | 205452_at | PIGB | 15 | 0.302 | 1.53E-04 | −0.287 | 2.22E-06 | −0.212 | 5.31E-03 |
rs7174876 | 15 | 53406853 | Intron | 0.423 | 205452_at | PIGB | 15 | 0.284 | 4.06E-04 | −0.261 | 1.64E-05 | −0.212 | 5.31E-03 |