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Table 3 Ingenuity pathway analysis of transcripts with higher expression between High-stressed females and Low-stressed females

From: Transcriptional responses of PBMC in psychosocially stressed animals indicate an alerting of the immune system in female but not in castrated male pigs

Canonical pathway Expression p-value Involved genes with altered mRNA abundances         
Dendritic cell maturation HSF > LSF 6.20E-04 Gene symbol CD1D ICAM1 IL1B IL1RN JAK2 MYD88 TLR2 TLR4 TNFRSF1A TNFRSF1B TRD@ TYROBP
    Fold Change +1.74 +1.56 +2.35 +3.07 +1.69 +1.85 +1.82 +3.71 +1.43 +1.79 +1.81 +1.92
IL-6 signaling HSF > LSF 7.69E-03 Gene symbol A2M CD14 CSNK2A1 IL1B IL1RN JAK2 TNFRSF1A TNFRSF1B     
    Fold Change +3.00 +3.89 +1.38 +2.35 +3.07 +1.69 +1.43 +1.79     
IL-8 signaling HSF > LSF 4.67E-02 Gene symbol GNG10 ICAM1 MYL2 PTGS2 RHOQ SRC TEK VASP     
    Fold Change +1.70 +1.56 +1.49 +2.62 +2.13 +1.51 +2.12 +1.26     
Toll-like receptor signaling HSF > LSF 1.83E-02 Gene symbol CD14 LY96 MYD88 TLR2 TLR4        
    Fold Change +3.89 +1.43 +1.85 +1.82 +3.71        
TREM 1 signaling HSF > LSF 3.22E-05 Gene symbol CASP1 ICAM1 IL1B JAK2 MYD88 TLR2 TLR4 TREM1 TYROBP    
    Fold Change +1.70 +1.56 +2.35 +1.69 +1.85 +1.82 +3.71 +2.80 +1.92    
  1. P-value: significance of association between dataset and IPA according to Benjamini-Hochberg multiple testing correction; Details regarding involved genes were displayed in Additional file 1.