Transcriptional responses of PBMC in psychosocially stressed animals indicate an alerting of the immune system in female but not in castrated male pigs

Table 3 Ingenuity pathway analysis of transcripts with higher expression between High-stressed females and Low-stressed females

Canonical pathway	Expression	p-value	Involved genes with altered mRNA abundances
Dendritic cell maturation	HSF > LSF	6.20E-04	Gene symbol	CD1D	ICAM1	IL1B	IL1RN	JAK2	MYD88	TLR2	TLR4	TNFRSF1A	TNFRSF1B	TRD@	TYROBP
			Fold Change	+1.74	+1.56	+2.35	+3.07	+1.69	+1.85	+1.82	+3.71	+1.43	+1.79	+1.81	+1.92
IL-6 signaling	HSF > LSF	7.69E-03	Gene symbol	A2M	CD14	CSNK2A1	IL1B	IL1RN	JAK2	TNFRSF1A	TNFRSF1B
			Fold Change	+3.00	+3.89	+1.38	+2.35	+3.07	+1.69	+1.43	+1.79
IL-8 signaling	HSF > LSF	4.67E-02	Gene symbol	GNG10	ICAM1	MYL2	PTGS2	RHOQ	SRC	TEK	VASP
			Fold Change	+1.70	+1.56	+1.49	+2.62	+2.13	+1.51	+2.12	+1.26
Toll-like receptor signaling	HSF > LSF	1.83E-02	Gene symbol	CD14	LY96	MYD88	TLR2	TLR4
			Fold Change	+3.89	+1.43	+1.85	+1.82	+3.71
TREM 1 signaling	HSF > LSF	3.22E-05	Gene symbol	CASP1	ICAM1	IL1B	JAK2	MYD88	TLR2	TLR4	TREM1	TYROBP
			Fold Change	+1.70	+1.56	+2.35	+1.69	+1.85	+1.82	+3.71	+2.80	+1.92

P-value: significance of association between dataset and IPA according to Benjamini-Hochberg multiple testing correction; Details regarding involved genes were displayed in Additional file 1.

ISSN: 1471-2164