Table 1 Seven pathways changed in the diabetic liver
From: A network biology workflow to study transcriptomics data of the diabetic liver
Pathway | Z-score | P-value | # Genes | Genes |
|---|---|---|---|---|
Triacylglyceride Synthesis | 3.78 | 0.001 | 3 / 19 | ↑ AGPAT2, GPD1, DGAT1 |
Proteasome Degradation | 3.32 | 0.006 | 5 / 53 | ↑RPN1, PSMB3, HLA-B, HLA-E, HLA-J |
Statin Pathway | 3.10 | 0.006 | 3 / 25 | ↑DGAT1, APOA4, CYP7A1 |
Fluoropyrimidine Activity | 2.84 | 0.013 | 3 / 28 | ↑SLC22A7 |
|  |  |  |  | ↓ABCG2, DPYD |
Pathogenic Escherichia coli infection | 2.76 | 0.011 | 4 / 46 | ↑ ARPC1A, ARPC1B, ACTB |
|  |  |  |  | ↓ ROCK1 |
Adipogenesis | 2.41 | 0.016 | 7 / 121 | ↑ SREBF1, CDKN1A, NR1H3, PNPLA3, AGPAT2 |
|  |  |  |  | ↓ CISD1, ZMPSTE24 |
AMPK Signaling | 2.38 | 0.029 | 4 / 54 | ↑ SREBF1, P21 |
|  |  |  |  | ↓ LEPR, PFKFB3 |