Table 1 20 top-scoring associations between drug-resistance profiles and point mutations in the case study on 173 fully sequenced M.tuberculosis strains.

Fluoroquinolones

Rv0006

gyrA

D94G/A/H/N/Y

Y

Y

14.1843430424

Isoniazid

Rv1908c

katG

S315T/G/N

Y

Y

9.04507605888

Rifampicin

Rv0667

rpoB

S450L

Y

Y

8.60191917013

Streptomycin

Rv0682

rpsL

K43R

Y

Y

8.32303955124

Ethambutol

Rv3795

embB

M306I/V/L

Y

Y

8.24966301883

Isoniazid

Rv1483

fabG1

C-15T

Y

Y

5.8445976648

Rifampicin

Rv0667

rpoB

D435F/V/Y/G/A

Y

Y

5.0402225732

Streptomycin

Rv0682

rpsL

K88R/M

Y

Y

4.16354931535

Ethambutol

Rv3795

embB

E504G/D

N

N

3.33103155053

Pyrazinamide

Rv2043c

pncA

W68L

Y

Y

2.7080502011

Pyrazinamide

Rv2043c

pncA

H51P

Y

Y

2.7080502011

Rifampicin

Rv0667

rpoB

H445D/Y/R

Y

Y

2.52993515037

Streptomycin

Rvnr01

rrs

G1108C

N

N

1.71691080314

Ethambutol

Rv3795

embB

D1024N

Y

N

1.68763546921

Ethambutol

Rv3795

embB

D869G

N

N

1.68763546921

Ethambutol

Rv3795

embB

A505T

N

N

1.68763546921

Fluoroquinolones

Rv0005

gyrB

N538T

Y

Y

1.68478734968

Fluoroquinolones

Rv0006

gyrA

S91P

Y

Y

1.68478734968

Fluoroquinolones

Rv0005

gyrB

T539I

N

N

1.68478734968

Streptomycin

Rvnr01

rrs

A1401G

Y

N

1.28846347057