Figure 5From: Mathematical model of the Tat-Rev regulation of HIV-1 replication in an activated cell predicts the existence of oscillatory dynamics in the synthesis of viral componentsKinetics of the Rev protein in the cell in relation to the oligomerization level in the complex with intron-containing viral mRNA and the provirus copy number in the genome. The model simulations in the absence of the Rev protein re-export from the nucleus and the complex formation of the Rev protein with the 9 kb RNAs and 4 kb RNAs in the cytoplasm. Upper panel corresponds to one proviral copy. Curve 1 corresponds to n Rev = 12, curve 2 is for n Rev = 10, curve 3 is for n Rev = 8, curve 4 is for n Rev = 6, curve 5 is for n Rev = 4, curve 6 is for n Rev = 3. Lower panel corresponds to 10 proviral copies. Curve 1 is for n Rev = 3 and curve 2 is for n Rev = 2. The vertical axis specifies the abundance of the free Rev molecules in the nucleus.Back to article page