From: High burden of private mutations due to explosive human population growth and purifying selection
Group | n= 100 | n= 492 | n= 1000 | n= 4299 | n= 10000 |
---|---|---|---|---|---|
Constant Population Size Model | 0.995% | 0.203% | 0.100% | 0.023% | 0.010% |
European History with Two Bottlenecks | 1.092% | 0.257% | 0.129% | 0.031% | 0.013% |
European History with Recent Growth | 1.406% | 0.750% | 0.596% | 0.349% | 0.237% |
NR Data | 1.444% (0.106%) | 0.756% (0.043%) | NA | NA | NA |
ESP Intergenic | 2.132% (0.123%) | 1.125% (0.049%) | 0.835% (0.034%) | 0.496% (0.019%) | NA |
ESP Intron | 2.233% (0.022%) | 1.171% (0.009%) | 0.922% (0.007%) | 0.528% (0.004%) | NA |
ESP Synonymous | 2.366% (0.026%) | 1.252% (0.012%) | 0.974% (0.009%) | 0.573% (0.005%) | NA |
ESP UTR | 2.492% (0.079%) | 1.305% (0.034%) | 1.004% (0.025%) | 0.596% (0.014%) | NA |
ESP Missense | 4.482% (0.049%) | 2.632% (0.026%) | 2.121% (0.019%) | 1.333% (0.011%) | NA |
ESP Nonsense | 10.04% (0.92%) | 7.37% (0.68%) | 6.00% (0.50%) | 4.46% (0.38%) | NA |
ESP Splice | 14.36% (2.29%) | 10.91% (1.50%) | 8.41% (1.19%) | 6.31% (0.91%) | NA |