From: GWAS and drug targets
 |  | Number of genes | Mean dN/dS | P Value for Mann-Whitney test against all genes | P Value for Mann-Whitney test against GWAS reported genes |
---|---|---|---|---|---|
Human-Mouse orthologs | All genes | 13691 | 0.22 | Â | Â |
 | GWAS reported genes | 2932 | 0.19 | 2.44e-09* |  |
 | Drug targets | 1035 | 0.18 | 1.21e-04* | 0.43 |
 | Drug targets with known mechanism | 432 | 0.17 | 6.04e-06* | 0.038* |
 | HGMD genes | 720 | 0.20 | 1.0 |  |
Human-Chimpanzee orthologs | All genes | 14173 | 0.44 | Â | Â |
 | GWAS reported genes | 2911 | 0.36 | 1.26e-13* |  |
 | Drug targets | 1020 | 0.33 | 2.78e-13* | 0.0098* |
 | Drug targets with known mechanism | 423 | 0.32 | 4.20e-08* | 0.013* |
 | HGMD genes | 699 | 0.36 | 0.002* |  |